Blood-Brain Barrier-on-a-Chip
The blood-brain barrier (BBB) is a critical multicellular structure that regulates the exchange of substances between the brain and the bloodstream, thereby maintaining brain homeostasis. A prominent innovation in studying this complex barrier is the blood-brain barrier-on-a-chip. This cutting-edge technology replicates the physiological and structural environment of the BBB more accurately than traditional models, offering enhanced research opportunities in the fields of neuroscience, pharmacology, and personalized medicine.
The BBB-on-a-chip design typically comprises two microfluidic channels separated by a porous membrane. One channel is dedicated to blood flow with endothelial cells, while the other mimics brain tissue, hosting neurons, astrocytes, and pericytes. Such a setup facilitates dynamic co-culture experiments, allowing researchers to study substance exchange, cellular interactions, and drug transport across the BBB under conditions that mimic real physiological shear stress and flow dynamics.
Our Products
At Alfa Chemistry, we leverage two decades of expertise to offer an unparalleled range of blood-brain barrier-on-a-chip products. Our key products boast the following features:
| Item/Catalog | MF-OC07 |
| Chamber Height | 100 μm |
| Center Chamber Diameter | 1.5 mm |
| Peripheral Chamber Width | 100 μm |
| Connecting Channel Dimensions | 3*3*3 μm |
| Opening Dimensions | 0.7 mm |
| Material | PDMS |
Key Features
- Microfluidic Precision: Our chip design ensures accurate control over environmental conditions, mirroring the in vivo BBB environment.
- Dynamic Culture System: Enables long-term co-culture of different cell types essential for functional BBB representation.
- Integrated Imaging Capabilities: Facilitates real-time monitoring and data collection, supporting advanced experimental procedures.
Applications
The blood-brain barrier-on-a-chip technology by Alfa Chemistry is versatile and finds its applications across various domains of biomedical research:
- Drug Discovery and Development
The chip provides a robust platform for screening and evaluating drug permeability and efficacy specific to CNS therapeutics, thereby accelerating the drug development process and ensuring better predictability of drug behavior in human models.
- Neurodegenerative Disease Modeling
By allowing researchers to observe cellular interactions and responses within a simulated BBB environment, our chip aids in elucidating pathogenetic mechanisms of diseases such as Alzheimer's and Parkinson's.
- Toxicology Testing
This technology offers a reliable method for assessing the neurotoxicity of pharmaceuticals and environmental agents, minimizing reliance on animal testing and improving safety evaluations.
- Personalized Medicine
The ability to customize the on-chip environment to mimic individual patient-specific conditions makes it an invaluable tool for tailored therapeutic interventions and personalized healthcare solutions.
Why Choose Us
- Proven Expertise: With over 20 years of industry experience, Alfa Chemistry stands at the forefront of microfluidic innovation, delivering reliable and high-precision products.
- Comprehensive Support: Our commitment extends beyond delivering top-tier products; we provide extensive technical support, bespoke training, and consulting services to ensure our clients achieve groundbreaking results.
- Customization and Quality: Each chip is crafted with precision and quality at its core, with customization options available to cater to specific research needs, ensuring maximal relevance and impact of experimental outcomes.
Alfa Chemistry's dedication to advancing microfluidic and organ-on-chip technologies is reflected in our superior products and services. The blood-brain barrier-on-a-chip is a testament to our continuous pursuit of excellence and innovation, addressing critical challenges in neuroscience and beyond.
Our products and services are for research use only.
