Lung-on-a-Chip Products
The field of biomedical research constantly strives for innovations that provide accurate simulations of human organs to better understand disease mechanisms and drug interactions. The lung-on-a-chip technology stands out as a groundbreaking development in this endeavor. By replicating the complex architecture and dynamic environment of human lungs on microfluidic chips, researchers can explore respiratory functions and pathologies in unprecedented detail. Alfa Chemistry is at the forefront of this technological revolution, offering state-of-the-art solutions to laboratories worldwide.
What is Lung-on-a-chip?
Lung-on-a-chip is a microengineered device designed to mimic the structure and function of a human lung in a controlled laboratory setting. This intricate system consists of microchannels lined with human alveolar and vascular endothelial cells, separated by a permeable membrane. The chip can simulate various physiological activities, such as breathing movements, by applying cyclical mechanical strain to the cell layers. This functionality allows researchers to observe important exchanges like oxygen and carbon dioxide, as well as cellular responses to pathogens, particulates, and pharmaceuticals in real-time.
Our Products
Alfa Chemistry provides cutting-edge lung-on-a-chip devices, thoughtfully designed to meet a wide range of research needs. Our key products are as follows:
| Item/Catalog | MF-OC01 | MF-OC02 | |
| Overall Dimension | 30*15 mm | 30*15 mm | |
| Channel | Height | 0.5 mm | 0.5 mm |
| Width | 1 mm | 1 mm | |
| Space | 0.2 mm | 0.5 mm | |
| Microporous Membrane | Thickness | 25 μm | 25 μm |
| Hole Diameter | 8 μm | 8 μm | |
| Material | PDMS | PDMS | |
Experimental Methods for Lung-on-a-chip
The lung-on-a-chip device offers a cutting-edge approach for simulating lung functions and studying respiratory diseases. Below are the core experimental methods:
- Chip Design and Fabrication: Using CAD tools, microfluidic chips are designed and fabricated with materials like PDMS through techniques such as soft lithography or 3D printing, ensuring precise microchannel and membrane construction.
- Cell Seeding and Culture: Lung cells, including alveolar epithelial and vascular endothelial cells, are seeded and co-cultured on the chip. Controlled conditions promote growth and differentiation, mimicking the native lung environment.
- Breathing Simulation: Cyclic mechanical strain is applied using micro-pumps or vacuum systems to replicate lung breathing movements, providing realistic mechanical stimulation for cell studies.
- Gas Exchange Modeling: The chip simulates oxygen and carbon dioxide exchange by introducing controlled gas mixtures, mimicking alveolar-capillary interactions.
- Drug Screening and Toxicity Tests: Drugs or toxins are introduced into the chip to evaluate their effects on cells, enabling efficient screening of therapeutic efficacy and potential side effects.
- Data Collection and Analysis: Integrated sensors and imaging systems enable real-time monitoring of cellular responses and biochemical processes, with advanced tools aiding data analysis.
Why Choose Us
At Alfa Chemistry, we empower biomedical research with advanced lung-on-a-chip technologies, driving innovation in respiratory science. Here's why researchers worldwide choose us:
- Precision Engineering: Our lung-on-a-chip devices are crafted using state-of-the-art methods like soft lithography and microfabrication, ensuring exceptional reliability and reproducibility.
- Customizable Solutions: We tailor our devices to meet your specific research needs, from unique cell types to custom channel dimensions and mechanical strain settings.
- Expert Support: Our team of experienced engineers and biomedical researchers provides comprehensive technical guidance, helping you optimize experimental setups and achieve reliable results.
Elevate your research with our cutting-edge lung-on-a-chip devices. From studying lung physiology to pioneering therapies for respiratory diseases, Alfa Chemistry is your partner for success. Contact us today to explore your options!
Our products and services are for research use only.
