Microfluidic Cell Sorting

Microfluidic Cell Sorting

Many research applications require the sorting and separation of cells from heterogeneous cell mixtures, or the separation of rare cells, such as circulating tumor cells, from blood samples. Based on these growing demands, this has increased the demand for cell sorting equipment. Compared with conventional devices, the microfluidic device is easy to use, smaller in size, versatile and reasonably priced.

Advantages of Microfluidic Cell Sorting

Microfluidic-Cell-Sorting

The cell sorter is one of the most successful commercial microfluidic devices. Compared with conventional methods, the microfluidic device uses a variety of technologies to sort cells, thereby achieving high speed and high efficiency.

From large-capacity cell sorters to precise single-cell sorters, microfluidic chips can be implemented. The modular nature of the chip allows it to be integrated with other chips to form a more complex system. For example, a cell sorter can be linked to a cell dispenser to allow single-cell distribution.

The use of microchips for cell sorting and cell separation has many advantages as follows:

  • In contrast to conventional cell sorters, microfluidic cell sorters usually operate in a smaller space.
  • The cost of purchasing a microfluidic cell sorter is much lower than traditional cell sorting systems.
  • The widely used microfluidic manufacturing process makes it possible to manufacture and test prototypes inexpensively, and makes mass production cost-effective.
  • In conventional techniques, cell sorting usually requires one or more sample preparation steps, which prolongs the process and increases the risk of cross-contamination. However, in most cases, microfluidic chips can be integrated with each other for on-chip sample preparation.

How Does The Microfluidic Cell Sorting Device Work?

Like any other cell sorting device, the microfluidic cell sorting device also operates based on differences in specific parameters. The size of its operation allows cells to be classified according to very subtle differences in inherent parameters.

Microfluidic-Cell-Sorting

The cell mixture enters the microfluidic chip and passes through the microfluidic channel. Units with different properties will be subjected to different forces, while similar units will be subjected to the same force. This force may originate from inertia in the chip microchannel, geometric patterns or obstacles, external sources, etc. The difference between these forces causes the cells to differentiate and push them to different streamlines.

How to Get Your Microfluidic Cell Sorting Device?

The high-level microfluidic technology team and years of development experience in the field of microfluidic chips make Alfa Chemistry a leading cell sorting equipment expert in the industry. Our team will be happy to help you manufacture your microfluidic cell sorting equipment.

We can provide you with professional knowledge based on microfluidic technology, high-quality cell sorting chip design, and customized services. Our microfluidic cell sorting technology includes:

If you need additional help, please contact us directly for more details.

Reference

  • Shields IV C. W, et al. (2015). "Microfluidic Cell Sorting: A Review of The Advances in The Separation of Cells From Debulking to Rare Cell Isolation." Lab Chip. 15: 1230-1249.

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