The currently used 2D monolayer cells cannot accurately reflect the structure and other characteristics of living tissue, nor can they replicate the complex and dynamic 3D environment in the body. “Organ-On-A-Chip” or tissue chips based on microfluidic technology are the most in-demand microfluidic chips on the market, which can revolutionize the pharmaceutical industry. They can simulate the complex structure, microenvironment, and physiological functions of human organs, and have gradually become an ideal tool for new drug screening and toxicity assessment.
Organ-On-A-Chip and Its Advantages
“Organ-On-A-Chip” is a miniature device based on microfluidic technology, which aims to create a more complex physiological environment to cultivate and control cells in the 2D or 3D structure of specific organs in the body.
Microfluidic scientists have created a bionic system on a microfluidic chip that can precisely control the microenvironment to mimic the natural physiological conditions of cells and the main functions of human organs. Compared with traditional 2D cell culture and animal models, microfluidic technology enables researchers to test drugs in a more realistic way in a preclinical environment.
How Does Organ-On-A-Chip Work?
Generally, a monolithic organ consists of a main microcavity lined with human cell lines, which can be connected to a microchannel network for perfusion and waste recovery. Micro chambers are simple chambers with micron-scale dimensions. The cell culture microcavity can be modified in many ways to help better simulate the natural environment of the cells. For example, modifying the surface with natural ECM-derived proteins can increase the adhesion of adherent cells to the surface. Microchambers are usually connected to multi-sided microchannels, which can be used to deliver nutrients, bacteria, viruses, and chemicals to cells, or to wash cells and discard waste.
Figure 1. Organ-on-a-chip systems for modeling organ fibrosis associated with tissue injury, aging, or a genetic disorder in a representative patient. (A) Biowire II integrated scar-myocardium model. (B) Liver sinusoid-on-a-chip and reconfigurable liver injury-on-a-chip. (C) 3D vascularized skeletal muscle model. (D) Customized Flexcell Tissue Train plate for modeling IPF. (E) Micropillar-suspended 3D lung interstitial microtissue comprised of fibroblasts and collagen (F) Foreign body response-on-a-chip. (Hayward K. L, et al. 2020)
In a more complex system, a single piece of organs related to different organs can be connected to each other to analyze multiple organs at the same time to build a more comprehensive model or study cell interactions. For example, the heart on the chip can be connected to the liver on the chip through its common blood vessel channel to test the cardiotoxicity of new drugs.
How to Obtain Organ-On-A-Chip?
With the development of organs on chips, the market demand for them continues to grow. Although you can buy off-the-shelf products, in many cases, "organs on a chip" need to be customized according to your own experimental specifications. Alfa Chemistry has a professional microfluidic technology team with many years of experience in design and microfluidic manufacturing and has helped customers successfully design and manufacture a variety of organ chips.
We can provide customers with professional, high-quality single-chip organ design and customization services based on microfluidic technology. Whether you are ready to design and want to manufacture on-chip organs at an affordable price, or have an idea for on-chip organs but have no design and manufacturing experience, we can help you. Please contact us immediately to purchase the organ on the chip at a high quality and reasonable price.
- Hayward K. L, et al. (2020). “Organ-on-a-Chip Systems for Modeling Pathological Tissue Morphogenesis Associated with Fibrosis and Cancer.” ACS Biomaterials Science & Engineering.
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