Tissue Chips

The microphysiological system (MPS), also known as "organ on a chip" or "tissue chip," uses the latest advances in cell biology, tissue engineering, and microfabrication to create in vitro models of human organs and tissues. These systems provide promising solutions for simulating human physiology and diseases in vitro and have multiple applications in areas where traditional cell culture and animal models are insufficient.

Alfa Chemistry has established a standardized process and quality control system for the mass production of high-throughput tissue chips and has developed nearly a thousand chip products of different densities and types. We can tailor the microfluidic chip for you according to your needs.

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About Alfa Chemistry's Tissue Chips

Alfa Chemistry's tissue chip technology can integrate tens to hundreds of tissue specimens from different individuals on a solid carrier. It is a high-throughput, large sample, and rapid molecular level analysis tool. Our researchers can effectively use hundreds of natural or diseased tissue specimens to study the correlation between specific genes and their expressed proteins and diseases, molecular diagnosis of diseases, prognostic indicators, and the location of therapeutic target antibodies. The screening of antibodies and drugs is very important. The microarray services we provide include cell phenotype analysis, gene amplification analysis, preparation of various microbiological and pathological maps, antibody screening, and screening/rapid verification of diagnostic markers and drug targets.

Applications of Our Tissue Chips

Cell Phenotype Analysis

Using standard immunohistochemical methods to detect various indicators on hundreds of different tumor tissue samples on the tissue chip, it can be found that these indicators are closely related to the diagnosis, differential diagnosis, and prognosis of tumors.

For Screening New Gene Targets

Using tissue microarray analysis of each candidate gene can find the most potential target genes of new drugs or inhibitors, or discover proto-oncogenes or new genes encoding signal transduction molecules. Tumor tissue chips are particularly suitable for selecting target genes when developing anti-tumor drugs.

Atlas of Microbiology and Pathology

Various microbiological and pathological maps can be prepared according to needs, such as normal tissue chips, various pathological types of tumor tissue chips, rare tumor tissue chips, and so on. It can be used for research, storage, and comparative research.

Gene Amplification Analysis

Tissue chip technology can also be used to detect the amplification or expression of several or dozens of genes at the same time. It can be used to find the regulation of various genes in many different tissue samples, and then obtain valuable experimental results based on these different regulatory conditions.

Individualized Tumor Treatment

Tissue microarrays can be used to screen a large number of tumor tissue samples to determine which tumors should be treated in which way.

Fig.1 Mimicking tissue-tissue and organ-organ interfaces in organomimetic microdevices. (Huh D, et al. 2012)

Research Methods Suitable for Tissue Microarrays

• HE staining
• Immunohistochemistry (IHC) staining
• In situ hybridization (ISH)
• Fluorescence in situ hybridization (FISH)
• In situ PCR
• In situ RT-PCR
• Oligonucleotide-initiated in situ DNA synthesis (PRINS)

Reference

• Huh D, et al. (2012). "Microengineered Physiological Biomimicry: Organs-on-Chips." Lab Chip. 12: 2156-2164.

Our products and services are for research use only.