COC Substrates

Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics consisting of cyclic olefin monomers (norbornene) and linear olefins (ethene). COC is characterized by good biocompatibility, low water absorption, good chemical resistance, and high transparency in the deep UV region. It is therefore ideally suited for bioanalytical and chemical reactions in microfluidic chips, such as for analyzing parameters like blood gases, glucose or lactate concentrations, or for determining erythrocyte pressurization levels. COC offers optical properties comparable to PMMA and higher heat resistance than PC, as well as superior dimensional stability compared to PMMA and PC.

COC substrates

Alfa Chemistry offers COC substrates applicable to the fabrication of microfluidic chips and can provide products customized to the specific needs of our customers.


Thickness1 mm
Diameter12 mm
Tensile strength60 MPa
Elongation at break 3%
Flexural modulus2500 MPa
Flexural strength100 MPa
Moisture permeability0.09%
Refractive index1.54


COC Substrates

The COC substrates provided by Alfa Chemistry have the following key advantages:

  • They have good resistance to hydrolysis, acidic reagents, alkaline reagents and most organic polar solvents such as acetone, methanol and isopropanol.
  • They have low water absorption, so changes in relative humidity in the environment do not significantly affect the devices they replicate.
  • They have good scratch resistance, good adhesion with inorganic and organic materials, easy to seal, and are suitable for microfluidic chip thermoplastic molding and medical device use.
  • They exhibit high transparency for light at wavelengths above 250 nm and have low autofluorescence, making them effective materials for use in microfluidic systems for bioassays using integrated circuits.

Choose Alfa Chemistry

Alfa Chemistry is a leading company in microfluidic devices and chips worldwide. We are committed to providing our customers with a wide range of microfluidic consumables and helping realize their designs. If you're looking for COC substrates, then you've come to the right place. Please do not hesitate to contact us. We are looking forward to being your partner.

Our products and services are for research use only.

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