Heart-on-a-Chip Products
The heart-on-a-chip is a groundbreaking innovation in cardiovascular research. This microfluidic device replicates the physiological and mechanical functions of the human heart, enabling rapid drug testing and analysis of heart cell reactions. By simulating heart mechanics in a controlled environment, lined with live cardiac cells, this cutting-edge technology marks a significant advancement in the study of cardiovascular diseases.
The Necessity of Heart-on-a-chip
Cardiovascular diseases are the leading cause of death worldwide, highlighting the urgent need for precise and reliable testing models. Traditional animal testing often falls short due to species differences that do not accurately predict human responses to cardiovascular drugs. This is where heart-on-a-chip technology emerges as a crucial tool, providing a promising alternative that alleviates ethical concerns associated with animal testing while significantly improving the accuracy of predicting cardiotoxicity and drug efficacy.
Our Products
We offer a range of heart-on-a-chip devices, including engineered heart tissue chips, tailored to diverse research needs. Our key products are as follows:
| Item/Catalog | MF-OC03 | MF-OC04 | MF-OC05 | MF-OC06 | |
| Number of Slots | 2 | 4 | 2 | 4 | |
| Antenna Size | Length | 10 mm | 10 mm | - | - |
| Diameter | 1 mm | 1 mm | - | - | |
| Space | 8.5 mm | 8.5 mm | - | - | |
| Slot Size | Length | - | - | 13.5 mm | 13.5 mm |
| Width | - | - | 12 mm | 12 mm | |
| Height | - | - | 3 mm | 3 mm | |
| Material | PDMS | PDMS | PTFE | PTFE | |
Experimental Methods for Heart-on-a-chip
- Design and Fabrication
The process begins with designing the chip layout to mimic the heart's structure. This involves integrating microchannels to simulate blood vessels and chambers for cardiac cell components such as cardiomyocytes and endothelial cells. Precision fabrication techniques, including photolithography and soft lithography, are employed to create these complex structures.
- Cell Culture and Assembly
Cardiac cells are cultured and seeded onto the chip to form structured tissue layers that replicate the heart's alignment and contraction properties. Advanced techniques like 3D printing may be used to enhance the structural fidelity and complexity of the heart model.
- Experimental Operation
The system meticulously controls the microenvironment, regulating parameters like fluid dynamics and temperature to accurately simulate physiological conditions. Mechanical and electrical stimulation mimic natural heart rhythms, enabling studies on drug responses and disease mechanisms.
- Data Analysis
High-resolution imaging and integrated sensors collect real-time data to assess drug effects and cardiac health. Technologies such as fluorescence microscopy allow detailed observation of cellular responses within the Heart-on-a-Chip, providing valuable insights into cardiac function and pathology.
Why Choose Us
Alfa Chemistry is a leader in providing exceptional organ-on-a-chip solutions, known for precision and reliability. Our dedication to innovation ensures that we deliver the most advanced and customizable heart-on-a-chip systems, supporting a wide array of research applications, from drug development to disease modeling.
By selecting our heart-on-a-chip products, you gain from our extensive expertise and commitment to quality. Our systems not only enhance research accuracy and efficiency but also reduce the necessity for animal testing, aligning with ethical research standards and cutting development costs. Our professional team is available to offer comprehensive support, helping our clients reach their research goals with increased confidence and success.
Our products and services are for research use only.
